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The FDA emphasized that Moonlight cigarettes are not necessarily safer, but Mitch Zeller, director of the FDA's Center for Tobacco Products, said that they show promise "to help reduce nicotine dependence among addicted smokers." The FDA reports that Moonlight cigarettes are not likely to turn non-smokers into smokers, and that those who do use them are not likely to become addicted to them

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Clinical data indicate that smoking adversely affects multiple aspects of liver disease, including the incidence and severity of hepatic steatosis, progression of fibrosis, development of HCC, and outcomes among alcohol-related liver transplant recipients [78, 79]